Data Management and Statistical

The core serves as a data collection and analytic hub for the UK-Alzheimer's Disease Research Center (ADRC) by:

  • Maintaining a centralized database of information collected by all cores and affiliated research projects;
  • Providing expertise on experimental design and statistical analyses; and,
  • Interacting dynamically with other cores to contribute to the clinical, neuropathological, and educational/ outreach of the ADRC.

One of the primary objectives of this core is to maintain a centralized database of all information collected by the ADRC cores, pilot projects, and Alzheimer's disease and aging research studies. Activities that support this objective include:

  • Ensuring confidentiality and security of data;
  • Developing data collection forms and entering data;
  • Providing monthly summaries to the ADRC Executive Committee;
  • Creating appropriate subsets of data for approved projects and investigators; and,
  • Reporting accurate and complete datasets to the National Alzheimer's Coordinating Center.

The core also provides expertise on experimental design and analysis to ADRC cores, pilot projects, and other aging and Alzheimer's disease research initiatives. Activities that support this objective include:

  • Consulting with investigators on all projects, grant submissions, presentations, and manuscripts;
  • Reviewing all ADRC pilot projects for statistical content;
  • Collaborating with other ADRCs on special projects of mutual interest; and,
  • Incorporating advances in statistical methodology to interpret and analyze data collected.

This core contributes to the literature with innovative studies on statistical methodology in Alzheimer's disease research and participates in the training of graduate students, postdoctoral researchers, and young investigators.

The data management and statistical core is investigating risk factors associated with the UK-ADRC transition/translation diagram (figure below left) by making the intervening states transient and accounting for the competing risk of death (figure below right) taken from Salazar et al., et al. Stat Med. 2007;26:568-580.


There is a wealth of information available on our longitudinal cohort. For example, our centralized database consists of clinical data on more than 4,700 subjects. This includes 1,000 subjects enrolled as cognitively intact at entry having more than 7,000 person years of follow-up and of these 266 have come to autopsy after more than 2,300 person years of follow-up. This is a critical resource for investigators, whose requests for snapshots of the centralized database have risen to an average of seven requests per month in the past year.

Link to Biospecimen, Data or Clinic Request for more information

To request data, contact Richard Kryscio, PhD, or Erin Abner, PhD, at (859) 218-3825. 

Richard Kryscio, PhD


Room 230
Sanders-Brown Center on Aging
800 S. Limestone St.
Lexington, KY

Phone Number

(859) 218-3863 (office)
(859) 257-4665(fax)


 Senior Investigators

  • Erin Abner, PhD
  • Frederick A. Schmitt, PhD
  • David Fardo, PhD

Senior Data ManagerTimothy Shannon
Data ManagerJosh Stalion
Data ManagerMichael Fawkes
Developer AnalystCasey Spires
Database AnalystJacob Crump